hrp0084p1-27 | Diabetes | ESPE2015

Activation of Insulin Signaling in Gastrocnemius after Central Leptin Infusion is Associated with an Increase in Proliferation and Muscle Fibre Size

Barrios Vicente , Burgos-Ramos Emma , Canelles Sandra , Rodriguez Amaia , Gomez-Ambrosi Javier , Chowen Julie A , Fruhbeck Gema , Argente Jesus

Background: Skeletal muscle is the largest tissue involved in the insulin-stimulated disposal of glucose, with its size being controlled by hormonal status, among other factors. Leptin plays a primary role in the regulation of glucose homeostasis with a substantial degree of insulin and leptin cross-talk in muscle. However, the relationship between the leptin’s central effects on insulin sensitivity in muscle and associated structural changes remain unclear.<p class="...